منابع مشابه
Immunotherapy for the Prevention and Treatment of Type 1 Diabetes
In the past 15 years, multiple clinical trials have attempted to find prevention for type 1 diabetes. The accompanying article by Bresson and von Herrath (1) reviews basic mechanisms underlying immunoprevention and immunotherapy of type 1 diabetes as well as selected human trials in the context of data from animal models. The second part of this minisymposium provides an overview of the recent ...
متن کاملImmunotherapy for the Prevention and Treatment of Type 1 Diabetes
T ype 1 diabetes is an autoimmune disease that causes the body to destroy insulin-producing -cells in the pancreas. Genetic susceptibility is a major component of the disease pathogenesis. Many of the genes involved in disease susceptibility are major players in coordinating immune response. For example, the major histocompatibility complex (MHC) class II genes, known as human leukocyte antigen...
متن کاملPrevention of type 1 diabetes.
This article discusses type 1 diabetes mellitus, which results from insulin deficiency caused by autoimmune destruction of the insulin-producing beta-cells in the pancreatic islets of Langerhans. The autoimmune response against islet beta-cells is believed to result from a disorder of immunoregulation. According to this concept, T lymphocytes (T cells) autoreactive to certain beta-cell constitu...
متن کاملPrevention of type 1 diabetes.
Prevention of loss of b cells in type 1 diabetes is a major goal of current research. Knowledge of the genetic susceptibility, increasing ability to predict who may be at risk, recognition of the potential clinical impact of residual insulin secretion after diagnosis, and development of new immunomodulatory agents have supported an increasing number of clinical trials to prevent b-cell loss. In...
متن کاملPrevention of type 1 diabetes.
INTRODUCTION/BACKGROUND Type 1 diabetes is a chronic autoimmune condition characterized by destruction of insulin-producing β cells within the pancreatic islets. It is associated with considerable morbidity and mortality. Incidence levels are rising worldwide. SOURCES OF DATA Pubmed search (Nov 2010) using keywords: Type 1 diabetes, prevention, trials, immunotherapy. AREAS OF AGREEMENT The ...
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ژورنال
عنوان ژورنال: Diabetic Medicine
سال: 2011
ISSN: 0742-3071
DOI: 10.1111/j.1464-5491.2011.03417.x